Mar 20, 2008 · Sequence and structure comparison for the four overlapping complexes in the C-terminus of p53. (A) Primary, secondary, and quaternary structure of p53 complexes. (B) The ΔASA for rigid association between the components of complexes for each residue in the relevant sequence region of p53. The two hatched bars indicate acetylated lysine residues. Chromosome Structure and Function - Free download as Powerpoint Presentation (.ppt), PDF File (.pdf), Text File (.txt) or view presentation slides online. Scribd is the world's largest social reading and publishing site.

TABLE 1.Examples of p53-interacting Proteins p53 domain involved in Selected p53-interacting protein Method interaction references Activating Transcription Factor 3 (ATF3) GST pull-down,co-IP FL 1 2.6. Structure-based selection of novel spiro-oxindole derivatives and testing in vitro. These structure-function studies suggested to us that maximizing van der Waals interactions between the hydrophobic groups of the inhibitors and MDM2 residues would allow us to develop more potent spiro-oxindole inhibitors of the p53-MDM2 interaction.